PSVIII-27 Flunixin meglumine does not inhibit hyperthermia induced by central administration of α-1-acid-glycoprotein, an acute phase protein, in sheep.
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چکیده
منابع مشابه
Acute-Phase Proteins: Alpha -1- Acid Glycoprotein
Acute-phase proteins are proteins whose plasma concentrations increase in response to inflammation. The variability in protein plasma levels, and following impact on drug binding extent, cause modifications in the mode of drug action, distribution, disposition and elimination. One of the most important acute phase proteins is a1-acid glycoprotein (AAG or AGP), principal binding protein for basi...
متن کاملToxicity of Flunixin Meglumine in Broiler Chickens
This study was designed to evaluate the toxicity of flunixin meglumine, a nonsteroidal anti-inflammatory drug which might serve as an alternate of diclofenac that has been shown to cause toxicity in vultures. Twenty five broiler chickens of five weeks of age were randomly divided into five equal groups and treated with flunixin meglumine at the dosage rate of 0, 1.25, 2.5, 5 and 10 mg/kg body w...
متن کاملEffect of intracerebroventricular injection of flunixin meglumine on PTZ-induced seizures in male rats
Introduction: Flunixin Meglumine (FM) is a nonsteroidal antiinflammatory drug (NSAID) and nonselective cyclooxygenase (COX) inhibitor. Since it has been suggested that COX enzyme plays a role in seizure, this research is performed to assess the therapeutic effects that this compound might have in seizures induced by PTZ. Methods: In this research, male wistar rats (200 ± 20 g) were given int...
متن کاملEffect of the administration of flunixin meglumine on pregnancy rates in Holstein heifers.
Fifty-two 15-month-old Holstein heifers were synchronised with single or double injections of prostaglandin F(2alpha), followed by an injection of gonadotrophin-releasing hormone (gnrh) 48 hours later, and inseminated 12 to 14 hours after the injection of gnrh (day 0). Half of them were then injected twice intramuscularly with 1.1 mg/kg flunixin meglumine 12 hours apart, on the evening of day 1...
متن کاملPharmacokinetics of flunixin meglumine in mature swine after intravenous, intramuscular and oral administration
BACKGROUND The purpose of this study was to determine intravenous (IV), intramuscular (IM) and oral (PO) FM PK in mature swine. Appropriate pain management for lameness in swine is a critical control point for veterinarians and producers, but science-based guidance on optimal housing, management and treatment of lameness is deficient. Six mature swine (121-168 kg) were administered an IV, IM, o...
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ژورنال
عنوان ژورنال: Journal of Animal Science
سال: 2018
ISSN: 0021-8812,1525-3163
DOI: 10.1093/jas/sky404.068